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Astatine
Astat Informationen, einschließlich Technische Daten, Safety Data und seine Eigenschaften, Forschung, Anwendungen und andere nützliche Fakten sind erörtert werden. Wissenschaftliche Fakten, wie die atomare Struktur, Ionisierungenergie, Fülle auf der Erde, Leitfähigkeit und thermischen Eigenschaften sind im Preis inbegriffen.

 

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Astat ist ein Block P, Gruppe 17, Periode 6 Element. Die elektronische Konfiguration [Xe] 4f14 5d10 6s2 6p5. In seiner elementaren Form Astat's CAS-Nummer ist 7440-68-8. Das Astat Atom hat einen Radius von 145.pm und es ist, Van der Waals Radius ist 200.pm.

Astat entdeckt wurde von Emilio Gino Segrè, Dale R. Corson und K. R. MacKenzie im Jahr 1940.

 

 

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Astat Abundance. The following table shows the abundance of Astat and each of its naturally occurring isotopes on Earth along with the atomic mass for each isotope.

Isotope
Atomic Mass
% Abundance on Earth
At-210
209.987131
-

Astat Safety Data. The safety data for Astat metal, nanoparticles and its compounds can vary widely depending on the form. For potential hazard information, toxicity, and road, sea and air transportation limitations, such as DOT Hazard Class, DOT Number, EU Number, NFPA Health rating and RTECS Class, please see the specific material or compound referenced in the left margin.

Ionisation Energie. Die Ionisierungenergie für Astat (die am wenigsten Energie benötigt, um ein einzelnes Elektron aus dem Atom in seinem Grundzustand in der Gasphase) ist in der folgenden Tabelle dargestellt:

1st Ionization Energy
- kJ mol-1
2nd Ionization Energy
- kJ mol-1
3rd Ionization Energy
- kJ mol-1

Conductivity. As to Astat's electrical and thermal conductivity, the electrical conductivity measured in terms of electrical resistivity @ 20 ºC is 16.9 µOcm and its electronegativities (or its ability to draw electrons relative to other elements) is 2.1. The thermal conductivity of Astat is 50.6 W m-1 K-1.

Thermal Properties of Astat. The melting point and boiling point for Astat are stated below. The following chart sets forth the heat of fusion, heat of vaporization and heat of atomization.

Heat of Fusion
23.81 kJ mol-1
Heat of Vaporization
585.22 kJ mol-1
Heat of Atomization
678 kJ mol-1



 
Formula Atomic Number Molecular Weight Electronegativity (Pauling) Density Melting Point
Boiling Point
Vanderwaals radius
Ionic radius Energy of first ionization
Atd 17 (210)  g.mol -1 2.2 - g·cm−3 302 °C 337 °C .200 nm - pm -  kJ.mol-1

PRODUCT CATALOG German Operations Submicron & Nanopowder Tolling Ultra High Purity Sputtering Target Crystal Growth Rod, Plate, Powder, etc. Foil
 
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Recent Research & Development for Astat



  • Therapeutic Efficacy of Astat-211-Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice. Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):572-9.

  • Preparation and evaluation of 211At labelled antineoplastic antibodies. J Pharm Pharm Sci. 2007;10(2):277s-285s.

  • Transport of free 211At and 125I- in thyroid epithelial cells: effects of anion channel blocker 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid on apical efflux and cellular retention. Nucl Med Biol. 2007 Jul;34(5):523-30. Epub 2007 Jun 8.

  • Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatination. Bioconjug Chem. 2007 Jul-Aug;18(4):1226-40. Epub 2007 Jun 21.

  • Radiopharmaceutical chemistry of targeted radiotherapeutics, Part 3: alpha-particle-induced radiolytic effects on the chemical behavior of (211)At. J Nucl Med. 2007 Jul;48(7):1190-6. Epub 2007 Jun 15.

  • Radioimmunotherapy with Astat-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma. Laryngoscope. 2007 Jun;117(6):1013-8.

  • Biodistribution of 211At labeled HER-2 binding affibody molecules in mice. Oncol Rep. 2007 May;17(5):1141-7.

  • A kit method for the high level synthesis of [211At]MABG. Bioorg Med Chem. 2007 May 15;15(10):3430-6. Epub 2007 Mar 12.

  • Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts. Radiat Res. 2007 Mar;167(3):312-8.

  • Biodistribution of free 211At and 125I- in nude mice bearing tumors derived from anaplastic thyroid carcinoma cell lines. Cancer Biother Radiopharm. 2006 Dec;21(6):591-600.

  • Transport of free 211At and 125I- in thyroid epithelial cells: effects of anion channel blocker 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid on apical efflux and cellular retention. Nucl Med Biol. 2007 Jul;34(5):523-30. Epub 2007 Jun 8.

  • Radiopharmaceutical chemistry of targeted radiotherapeutics, Part 3: alpha-particle-induced radiolytic effects on the chemical behavior of (211)At. J Nucl Med. 2007 Jul;48(7):1190-6. Epub 2007 Jun 15.

  • Radioimmunotherapy with Astat-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma. Laryngoscope. 2007 Jun;117(6):1013-8.

  • A kit method for the high level synthesis of [211At]MABG. Bioorg Med Chem. 2007 May 15;15(10):3430-6. Epub 2007 Mar 12.

  • Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts. Radiat Res. 2007 Mar;167(3):312-8.

  • Biodistribution of free 211At and 125I- in nude mice bearing tumors derived from anaplastic thyroid carcinoma cell lines. Cancer Biother Radiopharm. 2006 Dec;21(6):591-600.

  • Enhancing the effect of radionuclide tumor targeting, using lysosomotropic weak bases. Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):279-87.

  • Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with (211)At-MX35 F(ab')(2). Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4):1228-37.

  • Basis-set extensions for two-component spin-orbit treatments of heavy elements. Phys Chem Chem Phys. 2006 Nov 14;8(42):4862-5. Epub 2006 Sep 22.

  • Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma. Med Chem. 2005 Nov;1(6):611-8. PMID: 16787344 [PubMed - indexed for MEDLINE]

 

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